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BQR-695
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BQR-695图片
CAS NO:1513879-21-4
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
BQR695
NVP-BQR695
产品介绍
BQR695 是一种磷脂酰肌醇 4-激酶抑制剂,对于人类和疟原虫 PI4KIIIβ 的IC50值分别为 80 和 3.5 nM。

产品描述

BQR-695 is a phosphatidylinositol 4-kinase (PI4K) inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively.

体外活性

BQR695 shows no evidence of toxicity against mature red blood cells (RBCs), induces a schizont-stage arrest indistinguishable from that observed in imidazopyrazine-treated parasites and exhibits cross-resistance with the imidazopyrazine-resistant lines. Treatment with 0.5 μM of either KAI407 or BQR695 causes GFP-PHOsh2 to redistribute to the parasite plasma membrane, consistent with depletion of intracellular PI4P upon inhibition of PfPI4K function.

Cas No.

1513879-21-4

分子式

C19H20N4O3

分子量

352.394

别名

BQR695;NVP-BQR695

储存和溶解度

DMSO:100 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years