PI4KIIIbeta-IN-9 是一种PI4KIIIβ抑制剂，其 IC50=7 nM。它也抑制 PI3Kδ (IC50:125 nM) 和 PI3Kγ (IC50:1046 nM)。

PI4KIIIbeta-IN-9 is a potent inhibitor of PI4KIIIβ(IC50 of 7 nM). .

PI4KIIIbeta-IN-9 (Compound 9) shows weak inhibition of PI3KC2γ (IC50 ~1 μM), PI3Kα (~2 μM), and PI4KIIIα (~2.6 μM) and<50% inhibition at concentrations up to 20 μM for PI4K2α, PI4K2β, and PI3Kβ.?PI4KIIIbeta-IN-9 forms a crescent shape that conforms to the active site of PI4KIIIβ.?This molecule makes extensive contacts with PI4KIIIβ.PI4KIIIbeta-IN-9 also inhibits PI3Kδ and PI3Kγ with IC50s of 152 nM and 1046 nM, respectively.

1429624-84-9

C23H25N3O5S2

487.59

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years