Polyphyllin I 是从七叶一枝花中提取的生物活性成分，具有很强的抗肿瘤活性。它是JNK信号通路的激活剂，也是PDK1/Akt/mTOR信号传导的抑制剂。它诱导自噬，G2/M 期阻滞和细胞凋亡。

Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D has an anti-angiogenic effect. Polyphyllin D has toxicity in human RBCs as well as its underlying mechanism for the hemolysis and eryptosis/erythroptosis. Polyphyllin D has strong anticancer activity, can overcome drug resistance in R-HepG2 cells and elicit programmed cell death via mitochondrial dysfunction.

50773-41-6

C44H70O16

855.028

重楼皂苷I;重楼皂甙

DMSO:117 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years