δ-Tocotrienol 是一种维生素 E，存在于蔬菜，水果，种子，坚果，谷物和油等。维生素 E 是抗氧化剂、神经保护剂和抗癌剂，可以降低胆固醇和其他脂质，保护心血管疾病。

δ-Tocotrienol is a potential angiogenic inhibitor. δ-Tocotrienol is also a nontoxic activator of mir-34a which can inhibit nonsmall cell lung cancer cells (NSCLC) cell proliferation, induce apoptosis and inhibit invasion, and thus offering a potential starting point for the design of novel anticancer agents.

δ-Tocotrienol induced apoptosis and cell cycle arrest at G0/G1 and M phases in nasopharyngeal carcinoma cells. After CNE1 cells were treated with δ-Tocotrienol, 169 genes were up-regulated and 167 down-regulated. ERK1/2 was shown to play a vital role in cell cycle arrest by gene chips. δ-Tocotrienol induces cell cycle arrest in CNE1 cells via the p16/CDK4/cyclin D1 signaling pathway. CNE1 apoptosis was related to dysregulated expression of Bax-2 and Bcl-2. Furthermore, caspase-3, -8, -9 up-regulation was related to the apoptotic effect of δ-Tocotrienol[1].

25612-59-3

C27H40O2

396.61

δ-生育三烯酚;Delta-Tocotrienol

DMSO:100 mg/mL (252.14 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years