TC-S 7005是一种有效的Polo样激酶的抑制剂,PLK1、PLK2和PLK3的IC50值分别为214 nM,4 nM和24 nM。
产品描述
TC-S 7005 is an effective inhibitor of Polo-like kinases (IC50s: 214 nM, 4 nM and 24 nM for Plk1, Plk2, and Plk3).
体外活性
In human SR fibroblasts, TC-S 7005(1 μM) obviously causess myofibroblast differentiation and decrease fibroblast proliferation rates [2].
Cas No.
1082739-92-1
分子式
C21H17N3O3
分子量
359.385
储存和溶解度
DMSO:100 mg/mL (278.3 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years