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Centrinone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Centrinone图片
CAS NO:1798871-30-3
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
LCR-263
产品介绍
Centrinone 是 polo 样激酶 4 的可逆抑制剂,对PLK4的Ki值为0.16 nM。

产品描述

Centrinone (LCR-263) is a reversible inhibitor of polo-like kinase 4 (PLK4; Ki:0.16 nM).

体外活性

Centrinone (LCR-263) treatment causes centrosome depletion in human and other vertebrate cells and it treatment reduces centriole number in multiciliated Xenopus epithelial cells, which indicates that Plk4 also controls centriole amplification in differentiated cells. Centrinone (LCR-263) treatment of HeLa human cervical carcinoma cells leads to a progressive reduction in foci containing centriolar and pericentriolar material markers at each round of cell division, until most cells lack centrioles and centrosomes. Centrosome loss irreversibly arrests normal cells in a senescence-like G1 state by a p53-dependent mechanism that is independent of DNA damage, stress, Hippo signaling, extends mitotic duration, or segregation errors[1].

Cas No.

1798871-30-3

分子式

C26H25F2N7O6S2

分子量

633.65

别名

LCR-263

储存和溶解度

DMSO:31 mg/mL (48.92 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years