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CFI-400945 free base
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CFI-400945 free base图片
CAS NO:1338806-73-7
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
CFI-400945 是一种有效的、选择性的、具有口服活性的 polo 样激酶 4(PLK4;Ki 值为 0.26 nM)的抑制剂。

产品描述

CFI-400945 is an potent, selective and orally active inhibitor of polo-like kinase 4(PLK4; Ki value of 0.26 nM).

体外活性

CFI-400945, a potent and selective PLK4 inhibitor.?Cancer cells treated with CFI-400945 exhibit effects consistent with PLK4 kinase inhibition, including dysregulated centriole duplication, mitotic defects, and cell death[1].

体内活性

Oral administration of CFI-400945 to mice bearing human cancer xenografts results in the significant inhibition of tumor growth at doses that are well tolerated[1].

Cas No.

1338806-73-7

分子式

C33H34N4O3

分子量

534.65

储存和溶解度

DMSO:100 mg/mL (187.04 mM),warmed with 50oC water bath
Ethanol:100 mg/mL (187.04 mM)
H2O:Insoluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years