YH-306 是 FAK 信号通路的调节剂。 YH-306 显示出抗肿瘤活性,抑制结直肠肿瘤的生长和转移。
产品描述
YH-306 is a modulator of the FAK signaling pathway that acts by suppressing colorectal tumor growth and metastasis.
体外活性
YH-306 suppresses the activation of FAK, c-Src, paxillin, and PI3K, Rac1, and the expression of MMP2 and MMP9. YH-306 potently suppresses uninhibited proliferation and induces cell apoptosis. YH-306 inhibits Arp2/3 complex-mediated actin polymerization[1].
Cas No.
1373764-75-0
分子式
C19H18N2O2
分子量
306.36
储存和溶解度
DMSO:15 mg/mL?(48.96 mM),ultrasonic and adjust pH to 1 with HCl
Powder: -20°C for 3 years
In solvent: -80°C for 2 years