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CRBN-6-5-5-VHL
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CRBN-6-5-5-VHL图片
CAS NO:2362575-45-7
包装:5mg
市场价:5336元

产品介绍
CRBN-6-5-5-VHL 是一种有效且选择性的基于 von Hippel-Lindau 的 cereblon (CRBN) 降解剂,DC50 值为 1.5 nM。 CRBN-6-5-5-VHL对新底物IKZF1和IKZF3的降解几乎没有影响。
Cas No.2362575-45-7
Canonical SMILESCC1=C(SC=N1)C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(CCCCOCCCCCOCCCCCCNC4=CC=CC(C(N5C6CCC(NC6=O)=O)=O)=C4C5=O)=O)C(C)(C)C)=O)=O)C=C2
分子式C51H69N7O10S
分子量972.21
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Potent and selective cereblon degrader (DC50 = 1.5 nM). Induces complete degradation of cereblon in MM1S cells. Comprises a cereblon E3 ligase ligand joined by a linker to a ligand for the E3 ligase VHL. Cell-permeable.

Steinebach et al (2019) PROTAC-mediated crosstalk between E3 ligases. Chem.Commun.(Camb) 55 1821 PMID:30672516