APY29 是 IRE1α 的变构调节剂；抑制 IRE1α 自磷酸化，IC50值为 280 nM，并激活 IRE1α RNase 活性。

APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity.

APY29 divergently modulates the RNase activity and oligomerization state of IRE1α by exerting their opposing effects on RNase activity through the same binding site. APY29 divergently affects IRE1α oligomerization. APY29 demonstrates opposing dose-dependent effects on ER stress-induced activation of the RNase of endogenous IRE1α[1].

1216665-49-4

C17H16N8

332.371

DMSO:33.24 mg/mL (100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years