Wee1-IN-3 是一种有效的Wee1激酶抑制剂，IC50小于 10 nM。它治疗癌症和其他增殖性疾病。

JUN76288 is a potent Wee1 kinase inhibitor with an IC50 of<10 nM. It treatment of cancer and other proliferative diseases.

WEE1-IN-3 inhibits cancer cell growth with IC50 values of 100-1000 nM and<100 nM for SW480 cells and H23 cells, respectively. ?WEE1 is overexpressed in various cancer types,?WEE1 kinase plays a role in the G2-M cell-cycle checkpoint arrest for ?ΝΑ repair before mitotic entry.?Normal cells repair damaged DNA during GI arrest.?Cancer cells often have a deficient G i-S checkpoint and depend on a functional G2-M checkpoint for DNA repair.

2272976-28-8

C28H31N7O2

497.603

JUN76288

DMSO:250 mg/mL (502.42 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years