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BTYNB
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BTYNB图片
CAS NO:304456-62-0
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
MDK6620
BTYNB IMP1 Inhibitor
产品介绍
MDK6620 是IMP1结合 c-Myc mRNA 的有效选择性抑制剂,IC50为 5 μM。它下调 β-TrCP1 mRNA 并减少NF-Κb的激活。它通过损害 IGF2 mRNA 结合蛋白 1 结合来破坏这种增强子功能,可用于癌症研究。

产品描述

MDK6620 is an inhibitor of the oncofetal mRNA-binding protein IMP1 (IC50 = 5 μM for IMP1 binding to c-Myc mRNA). MDK6620 downregulates β-TrCP1 mRNA and reduces activation of nuclear transcriptional factors-kappa B (NF-κB). It disrupts this enhancer function by impairing IGF2 mRNA-binding protein 1 (IGF2BP1)-RNA association

体外活性

In cells, BTYNB downregulates several mRNA transcripts regulated by IMP1.?BTYNB destabilizes c-Myc mRNA, resulting in downregulation of c-Myc mRNA and protein.?BTYNB downregulates β-TrCP1 mRNA and reduces activation of nuclear transcriptional factors-kappa B (NF-κB).?The oncogenic translation regulator, eEF2, emerged as a new IMP1 target mRNA, enabling BTYNB to inhibit tumor cell protein synthesis.?BTYNB potently inhibited proliferation of IMP1-containing ovarian cancer and melanoma cells with no effect in IMP1-negative cells.?Overexpression of IMP1 reversed BTYNB inhibition of cell proliferation.?BTYNB completely blocked anchorage-independent growth of melanoma and ovarian cancer cells in colony formation assays.?With its ability to target c-Myc and to inhibit proliferation of difficult-to-target melanomas and ovarian cancer cells, and with its unique mode of action, BTYNB is a promising small molecule for further therapeutic evaluation and mechanistic studies[1].

Cas No.

304456-62-0

分子式

C12H9BrN2OS

分子量

309.18

别名

MDK6620;BTYNB IMP1 Inhibitor

储存和溶解度

DMSO:62 mg/mL (200.53 mM)
Ethanol:4 mg/mL (12.94 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years