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MYCMI-6
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MYCMI-6图片
CAS NO:681282-09-7
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议

产品名称
NSC354961
产品介绍
MYCMI-6 是一种内源性MYC:MAX蛋白相互作用抑制剂,选择性结合 MYC bHLHZip 域,Kd值为 1.6 μM。它阻断 MYC 驱动的转录,以 MYC 依赖性的方式抑制肿瘤细胞的生长 ,诱导细胞凋亡。

产品描述

MYCMI-6 is a potent and selective inhibitor of endogenous MYC:MAX protein interactions,reduces proliferation and induces massive apoptosis in tumor tissue from a MYC-driven xenograft tumor model without severe side effects.

体外活性

MYCMI-6 in a cell-based protein interaction screen for small inhibitory molecules.?MYCMI-6 exhibits strong selective inhibition of MYC:MAX interaction in cells and in vitro at single-digit micromolar concentrations, as validated by split Gaussia luciferase, in situ proximity ligation, microscale thermophoresis and surface plasmon resonance (SPR) assays.?Further, MYCMI-6 blocks MYC-driven transcription and binds selectively to the MYC bHLHZip domain with a KD of 1.6 0.5 μM as demonstrated by SPR.?MYCMI-6 inhibits tumor cell growth in a MYC-dependent manner with IC50 concentrations as low as 0.5 μM, while sparing normal cells.?The response to MYCMI-6 correlates with MYC expression based on data from 60 human tumor cell lines and is abrogated by MYC depletion.?Further, it inhibits MYC:MAX interaction, reduces proliferation and induces massive apoptosis in tumor tissue from a MYC-driven xenograft tumor model without severe side effects.

体内活性

MYCMI-6 ?induces massive apoptosis and reduces tumor cell proliferation, tumor microvasculature density and MYC:MAX interaction in a MYC-dependent xenograft tumor model[1].

Cas No.

681282-09-7

分子式

C20H19N7O

分子量

373.41

别名

NSC354961

储存和溶解度

DMSO:2.3 mg/mL (6.16 mM,Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years