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VH 032,phenol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
VH 032,phenol图片
CAS NO:2244684-42-0
包装:50mg
市场价:5850元

产品介绍
VH 032,苯酚是基于 VH032 的 VHL 配体。 VH 032,苯酚可以通过接头连接到蛋白质的配体上,形成PROTAC。
Cas No.2244684-42-0
Canonical SMILESCC1=C(C2=CC=C(C(O)=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(C)=O)=O)O)=O)SC=N1
分子式C24H32N4O5S
分子量488.6
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC® research and development; incorporates an E3 ligase ligand with terminal hydroxyl ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Maniaci et al (2017) Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat.Comm. 8 830 PMID:29018234