Metoprine 是一种有效的组胺 N-甲基转移酶抑制剂，具有抗肿瘤活性。它是一种二氨基嘧啶衍生物，可以透过血脑屏障，并通过抑制 HMT 增加脑组胺水平。

Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity.

In mammals, histamine N-methyltransferase (HMT) is the sole enzyme responsible for degrading histamine in the brain.?Metoprine, one of the most potent HMT inhibitors, can cross the blood-brain barrier and increase brain histamine levels by inhibiting HMT.?Consequently, this compound can be a candidate for a prototype of drugs for the treatment of METH overdose[1].

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C11H10Cl2N4

269.13

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years