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Kuwanon H
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Kuwanon H图片
CAS NO:76472-87-2
包装与价格:
包装价格(元)
10 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
Kuwanon H 是分离自桑白皮的黄酮类化合物,具有拮抗非肽类蛙皮素受体的活性。Kuwanon H 特异性抑制细胞内胃泌激素释放肽 CRP 与GRP-preferring 受体的结合,Ki为 290 nM。

产品描述

Kuwanon H is a specific antagonist for the gastrin-releasing peptide (GRP) -preferring receptor with Ki values of 290 nM and can be useful for studying the physiological and pathological role of GRP. Kuwanon H is a potent non-peptide bombesin receptor antagonist.

体外活性

Kuwanon G and H, isolated from the methanol extract of Morus bombycis, inhibited specific binding of [125I]gastrin-releasing peptide (GRP) to GRP-preferring receptors in murine Swiss 3T3 fibroblasts with Ki values of 470 and 290 nM, respectively. Kuwanon H was one order of magnitude less potent for inhibiting [125I]bombesin binding to neuromedin B (NMB)-preferring receptors in rat esophagus membranes. This compound antagonized bombesin-induced increases in the cytosolic free calcium concentration and GRP-induced DNA synthesis in Swiss 3T3 cells.

Cas No.

76472-87-2

分子式

C45H44O11

分子量

760.82

储存和溶解度

DMSO:50 mg/mL (65.72 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years