PAR-4 Agonist Peptide, amide TFA 是一种蛋白酶激活受体 4 (PAR-4) 激动剂，对 PAR-1 或 PAR-2 均无影响，其作用可被 PAR-4 拮抗剂阻断。

PAR-4 Agonist Peptide, amide TFA is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist.

SCID mice have a significantly greater abdominal response to colorectal distension (CRD) at the distension levels of 0.04 to 0.1 mL increasing the intensity of EMG response by 384% to 132%, respectively (P<0.01; P<0.01; P<0.01; P<0.001) when compared with their BALB/cBy controls. PAR-4 activation effectively reverses this hypersensitivity (P<0.01, P<0.05; P<0.05; P<0.05)[1].

1228078-65-6

C36H49F3N8O9

794.83

AY-NH2 (TFA);PAR-4-AP (TFA)

DMSO:250 mg/mL (314.54 mM)
H2O:100 mg/mL (125.81 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years