您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > CN128
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
CN128
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CN128图片
CAS NO:1335282-05-7
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
CN128 (CN328) 是一种具有口服活性和选择性的铁螯合剂。
Cas No.1335282-05-7
别名CN328
Canonical SMILESCC1=C(O)C(O)=CC=[N+]1[C@H](CC2=CC=CC=C2)CO.[Cl-]
分子式C15H18ClNO3
分子量295.76
溶解度Methanol: 5mg/mL,Methanol:PBS (pH 7.2) (1:1): 0.5mg/mL
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CN128 is an orally active and selective iron chelator. CN128 is used for the research of β-thalassemia[1].

CN128 possesses a high selectivity for iron(III) over others metals[1].

CN128 (450 μmol/kg; p.o.) exhibits a good iron scavenging efficacy in rat[1].The iron removal efficacies of CN128 displays a dose-dependent behavior[1].CN128 lacks genetic toxicity[1].CN128 (75 μmol/kg; i.g.) possesses good oral bioavailability (82.6%), high maximal plasma concentration, and low clearance rats after an oral dose of 75 μmol/kg[1].CN128 is well-tolerated, with no mortality being observed at the higher dose levels in rats[1]. Animal Model: Male SD rats (300 g)[1]

[1]. Wenteng Chen, et al. CN128: A New Orally Active Hydroxypyridinone Iron Chelator. J Med Chem. 2020 Apr 23;63(8):4215-4226.