QS 11 是一种ARFGAP1抑制剂(EC50:1.5 μM)。QS 11 能抑制 ARFGAP 过表达的乳腺癌细胞迁移。QS 11 通过影响蛋白质运输来增强 Wnt/β-CATenin 信号。

QS 11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. Modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation. Also reduces in vitro migration of metastatic human breast cancer cells.

944328-88-5

C36H33N5O2

567.693

QS 11

Ethanol:100 mM
DMSO:100 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years