CCG-63808 是一种有效的、可逆的G蛋白信号调节子抑制剂。

CCG-63808 is a reversible inhibitor of regulator of G-protein signaling (RGS) proteins. CCG-63808 dose-dependently inhibits the TR-FRET signal between RGS4-AF488 and Tb-Gαo with IC50 values of 1.9 μM.

CCG-63808 showed selectivity among RGS proteins with a potency order of RGS 4 >19 = 16 >8 ? 7. CCG-63808 inhibited the GTPase accelerating protein activity of RGS4[1].

620113-73-7

C25H15FN4O2S

454.48

DMSO:1 mg/mL (2.20 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years