LPA2 antagonist 2 is ＞480-fold more selective than LPA3 (IC50 of 13.85 μM).LPA2 antagonist 2 is a selective LPA2 antagonist with an IC50 of 28.3 nM and a Ki of 21.1 nM.

Lysophosphatidic acid (LPA) is a phospholipid mediator that elicits a host of biological effects including cell proliferation, survival, motility and differentiation. ?LPA2 antagonist 2 inhibits LPA1 with an Imax of 59.0% at 30 μM[1].?LPA has been shown to regulate cancer cell invasion, metastasis, and resistance to both chemotherapeutics and radiation.

36840-10-5

C20H16N2O6

380.35

DMSO:83.33 mg/mL (219.09 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years