Kinetensin acetate(103131-69-7 free base) 是从经胃蛋白酶处理的人血浆中分离出来的。它是一种神经降压素样肽。

Kinetensin acetate is isolated from pepsin-treated human plasma.Kinetensin acetate is a neurotensin-like peptide.

The peptide kinetensin isolated from pepsin-treated human plasma induces a dose-dependent release of histamine when exposed to rat peritoneal mast cells. The threshold concentration is around 1 μM, the ED50 is 10 μM, and the optimal concentration of between 100 to 1000 μM released 80% of the total histamine. Kinetensin is 10 to 100 times less potent than neurotensin and equipotent with the opioid peptide dynorphin. The histamine release is clearly temperature-dependent, with no release occurring at 0 or 45 °C and with an optimum around 37 °C. The histamine release is significantly reduced in the absence of extracellular calcium[2].

Kinetensin also induces a dose-dependent increase in vascular permeability when injected intradermally into rats[2].

TP1116L

C58H89N17O13

1232.45

Kinetensin (human) acetate

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years