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Neurotensin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Neurotensin图片
CAS NO:39379-15-2
包装与价格:
包装价格(元)
1 mg电议
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议

产品介绍
Neurotensin 是一种 13 个氨基酸的神经肽,参与调节促黄体激素和催乳素的释放,并与多巴胺能系统有显着的相互作用。它作为细胞有丝分裂原,作用于各种结肠直肠癌和胰腺癌。

产品描述

Neurotensin is a 13 amino acid neuropeptide that is implicated in the regulation of luteinizing hormone and prolactin release and has significant interaction with the dopaminergic system.

体外活性

Neurotensin induces the expression of MIP-2, MCP-1, IL-1β and TNFα in murine microglial cells and stimulates IL-8 secretion in a non-transformed colon epithelial cell line stably transfected with the NTR. The high-affinity NTR is a member of the G-protein coupled receptor (GPCR) family that is present in a majority of human pancreatic and colorectal cancers. It suggests that Neurotensin (NT) may act in an endocrine fashion to affect tumor growth. Acting through the NTR1, Neurotensin is known to stimulate various signal transduction pathways, including intracellular calcium ([Ca2+]i), the mitogen-activated protein kinases (MAPKs), ERK and JNK, and various PKC isoforms. Treatment of HCT116 cells with Neurotensin (100 nM) significantly increases HCT116 cell migration (~3-fold) compared with vehicle treatment; pretreatment with Curcumin (10 μM) blocksthe stimulatory effect of NT on HCT116 cell migration. ctivation of MEK/ERK by NT and downstream induction of AP-1 transcription factors contributes to the proliferative effects of Neurotensin[1].

Cas No.

39379-15-2

分子式

C78H121N21O20

分子量

1672.953

储存和溶解度

DMSO:10mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years