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Gadolinium chloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Gadolinium chloride图片
CAS NO:10138-52-0
包装与价格:
包装价格(元)
25 mg电议
50 mg电议
100 mg电议
500 mg电议

产品介绍
Gadolinium chloride 是特殊的钙敏感受体激动剂,可用于研究心血管疾病。

产品描述

Gadolinium chloride is a calcium-sensing receptor (CaSR) agonist

体外活性

Gadolinium chloride (GdCl ) , a well-known Kupffer/foam cell inhibitor, at late stages of NPC liver disease and compared it with NPC1 genetic rescue in hepatocytes in vivo.?GdCl treatment successfully blocked the endocytic capacity of hepatic Kupffer/foam measured by India ink endocytosis, decreased the levels CD68-A marker of Kupffer cells in the liver-and normalized the transaminase levels in serum of NPC mice to a similar extent to those obtained by genetic Npc1 rescue of liver cells.?Gadolinium salts are widely used as magnetic resonance imaging (MRI) contrasts.?This study opens the possibility of targeting foam cells with gadolinium or by other means for improving NPC liver disease.?Synopsis: Gadolinium chloride can effectively rescue some parameters of liver dysfunction in NPC mice and its potential use in patients should be carefully evaluated.

Cas No.

10138-52-0

分子式

Cl3Gd

分子量

263.61

储存和溶解度

H2O:9.85mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years