您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Astressin acetate
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Astressin acetate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Astressin acetate图片
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议

产品名称
Astressin acetate (170809-51-5 Free base)
产品介绍
Astressin acetate 是促肾上腺皮质激素释放因子 (CRF) 的拮抗剂,对 CRF 结合蛋白具有低亲和力,对克隆垂体受体具有高亲和力 (Ki = 2 nM)。

产品描述

Astressin acetate is an antagonist of corticotropin releasing factor (CRF) with low affinity for the CRF binding protein and high affinity for the cloned pituitary receptor(Ki = 2 nM).

体外活性

Astressin acetate exhibits high affinity for cloned human CRF-RA1 stably expressed in CHO cells and high potency to inhibit ACTH secretion[2].

体内活性

Astressin acetate (i.c.v. 30 min before and 10 min after seizures) decreases damage in some hippocampal cell fields by as much as 84%. Astressin acetate protects even if administered only 10 min following excitotoxin exposure[1]. Astressin acetate is significantly more potent than any previously tested antagonist in reducing hypophyseal corticotropin secretion in stressed or adrenalectomized rats. Astressin acetate (30 and 100 μg/kg; i.v.) produces a significant decrease in ACTH levels at 45 and 90 min, respectively[2]. Astressin acetate significantly reverses the anxiogenic-like response induced by both social stress and i.c.v. rat/humanCRF (r/hCRF) on the elevated plus-maze, but fails to block the effects of r/hCRF-induced locomotor activity in a familiar environment[3].

Cas No.

TP1448L

分子式

C163H273N49O44

分子量

3623.21

别名

Astressin acetate (170809-51-5 Free base)

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years