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Verucerfont
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Verucerfont图片
CAS NO:885220-61-1
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
3-(4-甲氧基-2-甲基苯基)-2,5-二甲基-N-[(1S)-1-(3-甲基-1,2,4-恶二唑-5-基)丙基]吡唑并[1,5-A]嘧啶-7-胺
GSK561679
NBI77860
产品介绍
Verucerfont 是促肾上腺皮质激素释放因子受体 1 (CRF1) 拮抗剂,作用于 CRF1(IC50:6.1 nM),CRF2 (IC50>1000 nM)和 CRF-BP (IC50>1000 nM)。

产品描述

Verucerfont is an antagonist of corticotropin-releasing factor receptor 1 (CRF1) .

体内活性

Verucerfont potently blocked the HPA axis response to the dexamethasone-CRF test, but left alcohol craving unaffected.?Right amygdala responses to negative affective stimuli were significantly attenuated by verucerfont, but responses to alcohol-associated stimuli were increased in some brain regions, including left insula[1].

Cas No.

885220-61-1

分子式

C22H26N6O2

分子量

406.49

别名

3-(4-甲氧基-2-甲基苯基)-2,5-二甲基-N-[(1S)-1-(3-甲基-1,2,4-恶二唑-5-基)丙基]吡唑并[1,5-A]嘧啶-7-胺;GSK561679;NBI77860

储存和溶解度

DMSO:86.7 mg/mL (213.29 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years