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Arctiin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Arctiin图片
CAS NO:20362-31-6
包装与价格:
包装价格(元)
20 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Arctii
Arctigenin-4-glucoside
牛蒡子苷
NSC 315527
产品介绍
Arctiin 是一种从牛蒡种子中提取的植物木酚素,具有抗癌作用。

产品描述

Arctiin acts on an agonists of the adiponectin receptor 1 with anti-cancer effects.

体外活性

Arctiin induces growth inhibition and dephosphorylates the tumor-suppressor retinoblastoma protein in human immortalized keratinocyte HaCaT cells. The growth inhibition caused by arctiin is associated with the downregulation of cyclin D1 protein expression. The arctiin-induced suppression of cyclin D1 protein expression occurs in various types of human tumor cells, including osteosarcoma, lung, colorectal, cervical and breast cancer, melanoma, transformed renal cells and prostate cancer[1].

体内活性

Arctiin has anti-cancer properties in animal models. arctiin has a remarkable anti-tumor-promoting effect as seen in a two-stage carcinogenesis test of mouse skin tumors induced by 7,12-dimethylbenz[α]anthracene(DMBA) as an initiator and 12-Otetradecanoyl phorbol-13-acetate (TPA) as a promoter by topical and oral administration. It also has a protective effect on 2-amino-1-methyl-6- phenylimidazo[4,5-β]pyridine (PhIP)-induced carcinogenesis particularly in the mammary gland during the promotion period[1]. Arctiin is orally effective against either IFV-inoculated normal or 5-fluorouracil (5-FU)-treated mice[3].

细胞实验

HaCaT cells are plated at 1×105 cells in 25-mm-diameter dishes. Twenty-four hours after plating, various concentrations of arctiin are added to the culture medium. From the first to the third day after plating, the number of viable cells is counted by the trypan blue dye exclusion test.(Only for Reference)

Cas No.

20362-31-6

分子式

C27H34O11

分子量

534.558

别名

Arctii;Arctigenin-4-glucoside;牛蒡子苷;NSC 315527

储存和溶解度

Ethanol:93 mg/mL (174 mM)
H2O:37 mg/mL (69.2 mM)
DMSO:93 mg/mL (174 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years