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[Pyr1]-Apelin-13
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
[Pyr1]-Apelin-13图片
CAS NO:217082-60-5
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议

产品名称
[pGlu1]-Apelin-13
人牛吡啶APELIN-13
产品介绍
[Pyr1]-Apelin-13 是一种高效的、内源性 apelin 受体选择性激动剂。

产品描述

[Pyr1]-Apelin-13 is a potent and selective endogenous Apelin receptor (APJ) agonist.

体外活性

[Pyr1]-apelin-13 encapsulation in lipoPEG particles (lipoPEG-PA13) results in sustained and extended drug release both in vitro and in vivo[1].

体内活性

[Pyr1]-apelin-13 nanocarriers in a mouse model of pressure-overload induced heart failure demonstrate a sustainable long-term effect of [Pyr1]-apelin-13 in preventing cardiac dysfunction[1]. [Pyr1] apelin-13 (1, 5 μg) improves locomotor activity and reduces pain symptoms, cavity size and caspase-3 levels in rats. [Pyr1] apelin-13 (1, 5 μg) significantly increases thermal paw withdrawal latency. [Pyr1] apelin-13 in 5 μg dose also produces significant attenuation in paw withdrawal threshold than SCI animals from the second week post SCI[2].

Cas No.

217082-60-5

分子式

C69H108N22O16S

分子量

1533.82

别名

[pGlu1]-Apelin-13;人牛吡啶APELIN-13

储存和溶解度

H2O:50 mg/mL (32.60 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years