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Boc-NH-PEG3-CH2COOH
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Boc-NH-PEG3-CH2COOH图片
CAS NO:462100-06-7
包装:100mg
市场价:900元

产品介绍
Boc-NH-PEG3-CH2COOH是一种基于PEG的PROTAClinker,用于合成PROTAC。
Cas No.462100-06-7
别名5,8,11-三氧杂-2-氮杂十三烷二酸1-叔丁酯
Canonical SMILESO=C(OC(C)(C)C)NCCOCCOCCOCC(O)=O
分子式C13H25NO7
分子量307.34
溶解度DMF: 5 mg/ml,DMSO: 1 mg/ml,Ethanol: 30 mg/ml
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Boc-NH-PEG3-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[1]. Vollmer S, et al. Design, Synthesis, and Biological Evaluation of MEK PROTACs. J Med Chem. 2020 Jan 9;63(1):157-162.