| CAS NO: | 1260247-50-4 |
| 包装: | 25mg |
| 市场价: | 5400元 |
| Cas No. | 1260247-50-4 |
| 别名 | DADPS叠氮生物素 |
| Canonical SMILES | O=C(NCC(C)(O[Si](C1=CC=CC=C1)(OCCCCCCN=[N+]=[N-])C2=CC=CC=C2)C)CCOCCOCCOCCOCCNC(CCCC[C@@H]3SC[C@]([C@]3([H])N4)([H])NC4=O)=O |
| 分子式 | C43H67N7O9SSi |
| 分子量 | 886.18 |
| 溶解度 | DMSO: 100 mg/mL (112.84 mM) |
| 储存条件 | -20°, protect from light,unstable in solution, ready to use. |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Biotin-PEG4-amino-t-Bu-DADPS-C6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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