Sigma-1 receptor antagonist 1 是一种有效、特异性的 sigma-1 受体拮抗剂。 Sigma-1 receptor antagonist 1 具有抗神经性疼痛活性,可用于治疗神经性疼痛研究。
产品描述
Sigma-1 receptor antagonist 1 is an effective and selective antagonist of sigma-1 receptor. Sigma-1 receptor antagonist 1 exhibits antineuropathic pain activity and can be used in the treatment of neuropathic pain studies.
体外活性
Sigma-1 receptor antagonist 1 exhibits a high binding affinity to σ1R receptor with Ki of 1.06 nM and good σ-1/2 selectivity (1344-fold)[1].
体内活性
In mice formalin model and rats CCI models of neuropathic pain, Sigma-1 receptor antagonist 1 exerts dose-dependent antinociceptive effects[1].
Cas No.
1639220-19-1
分子式
C19H23Cl2N3O
分子量
380.31
储存和溶解度
DMSO:6 mg/mL (15.78 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years