BD1063 是有效选择性的sigma 1受体拮抗剂。

BD1063 is a potent and selective sigma 1(σ1) receptor antagonist(Ki = 9 nM).

BD 1063 dose-dependently reduced ethanol self-administration in sP rats (3.3–11 mg/kg) and withdrawn, dependent Wistar rats (4–11 mg/kg) at doses that did not modify mean ethanol self-administration in non-dependent Wistar controls[1]

Rats (controls, N=11;?dependent, N=9) were pretreated with BD-1063 (0, 4.4, 7 and 11 mg/kg of body weight, free base weights) using a within-subject Latin square design.?sP rats: Rats (N=9) were pretreated with BD-1063 (0, 3, 4.4, 7 and 11 mg/kg of body weight, free base basis) using a within-subject Latin square design[1].

206996-13-6

C13H20Cl4N2

346.12

BD1063

H2O:50 mg/mL (144.46 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years