| CAS NO: | 4727-31-5 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| Molecular Weight (MW) | 317.34 |
|---|---|
| Formula | C20H15NO3 |
| CAS No. | 4727-31-5 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 63 mg/mL (198.5 mM) |
| Water: <1 mg/mL | |
| Ethanol: 18 mg/mL (56.7 mM) | |
| Solubility (In vivo) | O=C(O)C1=CC=CC=C1C(NC2=CC=C(C3=CC=CC=C3)C=C2)=O |
| Synonyms | KGN |
| In Vitro | In vitro activity: Kartogenin induces chondrocyte differentiation from hMSCs by enhancing the nuclear localization of CBFβ, and protects articular chondrocytes. Kartogenin promotes the type-I collagen synthesis of dermal fibroblasts via activation of the smad4/smad5 pathway without obvious cytotoxicity on fibroblasts’ viability, morphology and survival. Cell Assay: For the cell viability assay, fibroblasts are seeded on six-well plates, followed by Kartogenin or DMSO treatment. According to the manufacturer’s instructions, cell viability and viability are assessed by AlamarBlue assay. |
|---|---|
| In Vivo | Kartogenin promotes cartilage repair in collagenase VII (10 μM)– and surgery (100 μM)-induced OA models in mice. Kartogenin (100 nM) also stimulats collagen synthesis in the mouse dermis. In addition, Kartogenin stimulates mouse limb skeletal growth and synovial joint development. |
| Animal model | Collagenase VII-induced OA mouse model and Surgery-induced OA mouse model |
| Formulation & Dosage | Dissolved in saline; 10 μM or 100 μM; Intra-articular injection |
| References | Biochem Biophys Res Commun. 2014 Jul 18;450(1):568-74; Science. 2012 May 11;336(6082):717-21. |
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