Nastorazepide 是一种选择性的、口服有效的1,5-苯并二氮杂环衍生物胃泌素/胆囊收缩素2(CCK-2)受体拮抗剂,具有抗肿瘤的潜能。
产品描述
Nastorazepide is a selective, orally available antagonist of gastrin/cholecystokinin 2 (CCK-2) receptor with potential antineoplastic activity.
体外活性
Nastorazepide binds to the gastrin/CCK-2 receptor, thereby preventing receptor activation by gastrin, a peptide hormone frequently associated with the proliferation of gastrointestinal and pancreatic tumor cells[1].
体内活性
Nastorazepide significantly inhibits the growth of subcutaneous xenografts of human pancreatic tumor cells in mice, and that Nastorazepide combined with gemcitabine prolonged survival in a pancreatic carcinoma orthotopic xenograft mice[1].
Cas No.
209219-38-5
分子式
C29H36N4O5
分子量
520.62
别名
Z-360
储存和溶解度
DMSO:30 mg/mL (57.63 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years