Ertugliflozin L-pyroglutamic acid 是一种特异性和口服活性的 hSGLT2 抑制剂，IC50 为 0.877 nM。 Ertugliflozin L-pyroglutamic acid 可用于治疗 2 型糖尿病的研究。

Ertugliflozin L-pyroglutamic acid is a selective and orally active hSGLT2 inhibitor with an IC50 of 0.877 nM. Ertugliflozin L-pyroglutamic acid can be used for studies about the treatment of type 2 diabetes mellitus.

Ertugliflozin L-pyroglutamic acid demonstrated >2000-fold selectivity for SGLT2 over SGLT[2].

The oral administration of Ertugliflozin L-pyroglutamic to rats acid showed concentration-dependent glucosuria[2].

1210344-83-4

C27H32ClNO10

566

PF-04971729 L-pyroglutamic acid;埃格列净

DMSO:125 mg/mL (220.85 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years