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SKI-178
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SKI-178图片
CAS NO:1259484-97-3
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
SKI-178 是一种鞘氨醇激酶-1(SphK1)和SphK2抑制剂,以 CDK1 依赖性方式诱导人急性髓性白血病细胞凋亡。

产品描述

SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during prolonged mitosis, mediated by SKI-178 leads to the simultaneous phosphorylation of the prosurvival Bcl-2 family members, Bcl-2 and Bcl-xl, as well as the phosphorylation and subsequent degradation of Mcl-1.

体外活性

SKI-178 is a multi-targeted agent that functions both as an inhibitor of the SphKs as well as a disruptor of the microtubule network.?SKI-178 induced apoptosis arises from a synergistic interaction of these two activities.?SKI-178 is safe and effective in mouse models of AML, supporting its further development as a multi-targeted anti-cancer therapeutic agent[1].

Cas No.

1259484-97-3

分子式

C21H22N4O4

分子量

394.431

储存和溶解度

DMSO:50 mg/mL (126.77 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years