Resistomycin 是一种五环聚酮抗生素，具有抗癌活性并诱导癌细胞凋亡。

Resistomycin, a pentacyclic polyketide antibiotic, possesses anticancer activity and induces apoptosis.

Resistomycin attenuates triple-negative breast cancer progression by inhibiting E3 ligase Pellino-1 and inducing SNAIL/SLUG degradation. Resistomycin displays a high affinity for GST-Pellino-1 (KD = 2.58 μM) as indicated by surface plasmon resonance[1]. Resistomycin treatment reduced the expression of SNAIL and SLUG in TNBC cells[1]. Resistomycin induced apoptosis and cycle arrest in human hepatocellular carcinoma cells by activating p38 MAPK pathway in vitro and in vivo[2].

20004-62-0

C22H16O6

376.36

Geliomycin;Heliomycin

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years