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TBOPP
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TBOPP图片
CAS NO:1996629-79-8
包装与价格:
包装价格(元)
1mg电议
5mg电议
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50mg电议
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产品介绍
TBOPP 是一种 DOCK1 的选择性抑制剂,其 IC50 为 8.4 μM。TBOPP 以高亲和力 (Kd 为 7.1 μM) 与 DOCK1 DHR-2 结构域结合,对广泛类型的肿瘤均具有抗肿瘤活性。
Cas No.1996629-79-8
Canonical SMILESO=C1C=CC(S(=O)(N2CCCC2)=O)=CN1CC(C3=CC=C(C4=CC=CC(C(F)(F)F)=C4)C=C3)=O
分子式C24H21F3N2O4S
分子量490.49
溶解度DMSO: 125 mg/mL (254.85 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

TBOPP is a selective inhibitor of DOCK1 with an IC50 of 8.4 μM. TBOPP binds to the DOCK1 DHR-2 domain with high affinity (Kd of 7.1 μM), has anti-tumor activity for broader types of tumors[1].

TBOPP (12.5 µM; 3 days; 3LL cells) treatment inhibits DOCK1-mediated invasion, macropinocytosis, and survival under the condition of glutamine deprivation without impairing the biological functions of the closely related DOCK2 and DOCK5 proteins[1]. Cell Viability Assay[1] Cell Line: 3LL cells

TBOPP (0.67 mg per mouse; administrated on days 0, 1, 3, and 5; for 2 weeks; C57BL/6 mice) treatment effectively suppresses metastasis of cancer cells in vivo and the number of lymphocytes in the spleen is not changed, the body weight is also unchanged between TBOPP-treated and non-treated mice[1]. Animal Model: C57BL/6 mice (6- to 8-week-old) with ex-3LL cells[1]

[1]. Tajiri H, et al. Targeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of DOCK1. Cell Rep. 2017 May 2;19(5):969-980.