您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > SN50 acetate(213546-53-3 free base)
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
SN50 acetate(213546-53-3 free base)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SN50 acetate(213546-53-3 free base)图片
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议

产品介绍
SN50 acetate (213546-53-3 free base) 是一种可渗透细胞的 NF-Κb 易位抑制剂。

产品描述

SN50 acetate is a cell permeable inhibitor of NF-κB translocation.

体外活性

Pretreatment with SN50 acetate results in a significant reduction in amount of PI-positive cells at 12, 24, and 48 h time-point post TBI compared with vehicle-treated groups[1]. Topical SN50 acetate suppresses nuclear factor-κB activation in local cells and reduces the incidence of epithelial defects/ulceration in healing corneas. Myofibroblast generation, macrophage invasion, activity of matrix metalloproteinases, basement membrane destruction, and expression of cytokines are all decreased in treated corneas compared with controls[2]. Treating the human gastric cancer cells SGC7901 with SN50 acetate could significantly enhance the effects of LY294002 on inducing cell death after 24 h[3]. SN50 can inhibit translocation of NF-kB and production of inflammatory cytokines that are implicated in lipopolysaccharide (LPS)-induced lung injury[4].

体内活性

Treatment with SN50 acetate accelerates the recovery of motor functional outcome from 1st to 4th day. Animals subjected to SN50 acetate pretreatment demonstrate a significant decrease in the visuospatial learning latencies relative to the control group at 7 and 8 days post-TBI. Pretreatment with SN50 acetate results in a significant reduction of NF-κB p65 protein levels from 6 to 48 h post-TBI and TNF-a protein levels from 12 to 48 h post-TBI[1].

Cas No.

T12942L

分子式

C131H234N36O31S

分子量

2841.55

储存和溶解度

H2O:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years