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SPD304 dihydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SPD304 dihydrochloride图片
CAS NO:1049741-03-8
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议

产品介绍
SPD304 dihydrochloride 是 TNF-α 的特异性抑制剂,IC50 为 22 μM。 SPD304 dihydrochloride 促进 TNF 三聚体的解离。

产品描述

SPD304 dihydrochloride is a selective inhibitor of TNF-α with an IC50 of 22 μM. SPD304 dihydrochloride promotes dissociation of TNF trimers.

体外活性

The survivability of aHSCs is significantly rescued by SPD304 dihydrochloride (2 μM). The production of lipid hydroxides and intracellular GSH are increased as well. GA (75 μM) and SPD304 dihydrochloride (2 μM) downregulate TRADD (almost 2-fold) and p–RIP3 (1.4–fold) compared to GA and promote the activation of caspase 8[4].

Cas No.

1049741-03-8

分子式

C32H34Cl2F3N3O2

分子量

620.53

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years