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JND3229
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
JND3229图片
CAS NO:2260886-64-2
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
JND3229 是一种可逆性的 EGFRC797S 抑制剂,对 EGFRL858R/T790M/C797S、EGFRWT 和 EGFRL858R/T790M 的 IC50 值分别为 5.8、6.8 和 30.5 nM。JND3229 具有较好的抗增殖活性,能有效地抑制体内肿瘤的生长。JND3229 可用于癌症,尤其是非小细胞癌的研究。

产品描述

JND3229 is a reversible EGFRC797S inhibitor with IC50 values of 5.8, 6.8 and 30.5 nM for EGFRL858R/T790M/C797S, EGFRWT and EGFRL858R/T790M, respectively. JND3229 has good anti-proliferative activity and can effectively inhibit tumour growth in vivo. JND3229 can be used in cancer research, especially in non-small cell carcinoma.

体外活性

JND3229 potently inhibits the proliferation of BaF3 cells (harboring the EGFRL858R/T790M/C797S and EGFR19D/T790M/C797Smutations), NCI-H1975 NSCLC cells (with EGFRT790M mutation) and A431 cancer cells (overexpressing EGFRWT) with IC50 values of 0.51, 0.32, 0.31 and 0.27 μM, respectively. JND3229 (0.1, 0.3, 1, 3, 10 μM; 2 h) potently inhibits the phosphorylation of EGFRL858R/T790M/C797S and EGFR19D/T790M/C797S in engineering BaF3 cells[1].

体内活性

JND3229 (10 mg/kg; i.p.; twice daily for 10 days) exhibits an obvious suppression of tumor growth, and shows target inhibition in vivo[1].

Cas No.

2260886-64-2

分子式

C33H41ClN8O2

分子量

617.18

储存和溶解度

DMSO:11.7mg/mL (19mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years