IC 86621 是一种选择性和可逆的 ATP 竞争性 DNA-PK 抑制剂,IC50 为 120 nM。 IC 86621 增加 DNA 双链断裂 (DSB) 诱导的抗肿瘤活性,其 EC50 为 68 μM,用于 DNA-PK 介导的细胞 DSB 修复。
产品描述
IC 86621 is a selective and reversible ATP-competitive inhibitor of DNA-PK with an IC50 of 120 nM. IC 86621 increases DNA double-strand break(DSB)-induced antitumor activity with an EC50 of 68 μM for DNA-PK mediated cellular DSB repair.
体外活性
In CD4+CD45RO- T cells, IC 86621 (0 nM, 50 nM, 100 nM) protects rheumatoid arthritis T cells from apoptosis[1].
Cas No.
404009-40-1
分子式
C12H15NO3
分子量
221.25
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years