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Brilliant Black BN
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Brilliant Black BN图片
CAS NO:2519-30-4
包装与价格:
包装价格(元)
5 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
E 151
亮黑1
产品介绍
Brilliant blACK BN 是一种偶氮染料和一种食品着色剂。它抑制 EV71 与其细胞脱壳因子亲环蛋白 A 之间的相互作用,是一种很有前途的抗 EV71 感染的抗病毒药物。

产品描述

Brilliant black BN (E151) is an azo dye and a food colorant. It is a promising antiviral agent against EV71 infection via inhibiting the interaction between EV71 and its cellular uncoating factor cyclophilin A.

体外活性

Brilliant black BN inhibited the infection EV71 -GFP at a concentration of 300 μM. Brilliant black BN exhibits the inhibition of EV71 -GFP as a dose-dependent manner in infected RD cells (IC50: 10.1 μM). Brilliant black BN is able to inhibit all tested 28 EV71, CVA16, and CVA6 strains. In rhabdomyosarcoma cells, 50% inhibitory concentration 29 of the dye E151 for various strains of EV71 ranged from 2.39 μM to 28.12 μM, whereas its 50% cytotoxic concentration is 1870 μM [2].

体内活性

Brilliant black BN (i.p.; 200 mg/kg; 14 days)exhibits mild illness with clinical scores less than 3 and subsequently recovered when compared with PBS-group. All E151 270 treated mice are completely protected throughout the experiment [2].

Cas No.

2519-30-4

分子式

C28H21N5NaO14S4

分子量

802.74

别名

E 151;亮黑1

储存和溶解度

DMSO:123 mg/mL (141.75 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years