Myristyl nicotinate

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Myristyl nicotinate

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

273203-62-6

包装与价格：

包装	价格(元)
10mM (in 1mL DMSO)	电议
100mg	电议
200mg	电议
500mg	电议

产品介绍

Myristyl nicotinate (Tetradecyl nicotinate) 是一种酯前药和 Nicotinic acid 的亲脂衍生物。Myristyl nicotinate 被开发用于将烟酸输送到皮肤中，以防止光化性角化病及其发展为皮肤癌。Myristyl nicotinate 显示刺激光损伤的皮肤中的表皮分化，增加皮肤 NAD 含量并增强人皮肤屏障。

Cas No.	273203-62-6
别名	肉豆蔻醇烟酸酯,Tetradecyl nicotinate
Canonical SMILES	O=C(C1=CC=CN=C1)OCCCCCCCCCCCCCC
分子式	C₂₀H₃₃NO₂
分子量	319.48
溶解度	DMSO: 9.62 mg/mL (30.11 mM)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Myristyl nicotinate (Tetradecyl nicotinate) is an ester prodrug and a lipophilic derivative of Nicotinic acid. Myristyl nicotinate is being developed for delivery of Nicotinic acid into the skin for prevention of actinic keratosis and its progression to skin cancer. Myristyl nicotinate shows to stimulate epidermal differentiation in photodamaged skin, increasing skin NAD content and strengthening the skin barrier[1][2]. Myristyl nicotinate (Tetradecyl nicotinate) is used for treatment and prevention of conditions that involve skin barrier impairment such as chronic photodamage and atopic dermatitis or for mitigating skin barrier impairment that results from therapy such as retinoids or steroids[2]. [1]. Catz P, et al. Simultaneous determination of myristyl nicotinate, nicotinic acid, and nicotinamide in rabbit plasma by liquid chromatography-tandem mass spectrometry using methyl ethyl ketone as a deproteinization solvent. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Dec 27;829(1-2):123-35. [2]. Jacobson MK, et al. Effect of myristyl nicotinate on retinoic acid therapy for facial photodamage. Exp Dermatol. 2007 Nov;16(11):927-35.