Homo-PROTAC pVHL30 degrader 1 是一种基于 PROTAC 的 pVHL30 降解剂。

Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC.

Homo-PROTAC pVHL30 degrader 1 dimerizes von Hippel-Lindau (VHL) with high avidity in vitro and induces rapid, potent, and proteasome-dependent self-degradation of VHL in different cell lines, in a highly isoform-selective fashion and without triggering a hypoxic response.

2244684-49-7

C58H82N8O14S2

1179.45

DMSO:150 mg/mL (127.18 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years