GaultHERin 是一种分离自 GaultHERia yunnanensis 中的天然水杨酸酯衍生物。它是一种非甾体类抗炎药，具有止痛和抗炎作用，与 Aspirin 相比没有胃溃疡作用。

Gaultherin has analgesic, and anti-inflammatory activities.Gaultherin lacks gastric ulcerogenic effect, because of it released salicylate in intestine slowly, not in stomach and it left the cyclooxygenase-1 unaffected, which was the source of cytoprotective prostaglandins in gastric epithelium.

The synthesis of Gaultherin (1) and its analogs was carried out to provide 11 glycosides under phase-transfer catalytic conditions. METHODS AND RESULTS: The activities of all synthesized compounds were evaluated by nitric oxide production inhibitory assay in vitro. Methyl 2-O-(4-O-β-d-galactopyranosyl)-β-d-glucopyranosylbenzoate (5f) showed significantly anti-nociceptive and anti-inflammatory effects by the evaluation in vivo. Structure-activity relationships within these compounds were discussed.

490-67-5

C19H26O12

446.4

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years