您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Eugenol
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Eugenol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Eugenol图片
CAS NO:97-53-0
包装:1 mL
市场价:150元

产品名称
丁香酚
4-Allyl-2-methoxyphenol
Allylguaiacol
Eugenic acid
4-Allylguaiacol
产品介绍
Eugenol是一种从丁香中发现的精油,抑制脂质的过氧化,具有抗菌,驱虫和抗氧化活性。

产品描述

Eugenol is a Standardized Chemical Allergen. The physiologic effect of eugenol is by means of Increased Histamine Release and Cell-mediated Immunity.

体外活性

Eugenol has antiproliferative effects in diverse cancer cell lines as well as in B16 melanoma xenograft model. Eugenol induces apoptosis in various cancer cells, including mast cells, melanoma cells and HL-60 leukemia cells. Eugenol at low dose (2 μM) has specific toxicity against different breast cancer cells. This killing effect is mediated mainly through inducing the internal apoptotic pathway and strong down-regulation of E2F1 and its downstream antiapoptosis target survivin, independently of the status of p53 and ERα. Eugenol inhibits also several other breast cancer related oncogenes, such as NF-κB and cyclin D1. Moreover, eugenol up-regulates the versatile cyclin-dependent kinase inhibitor p21WAF1 protein, and inhibits the proliferation of breast cancer cells in a p53-independent manner[2].

体内活性

Eugenol inhibits the proliferation of breast cancer cells in vivo as well. The inhibitory effect of eugenol on onco-proteins is also observed in vivo in tumor xenografts[2]. Eugenol (0.2, 1.0, 5.0 or 25 mg/kg) when given orally at three different times in relation to the time of CCl4 dosing (i.p administration of 0.4 mg/kg), i.e. prior to (-1 hr), along with (0 hr) or after (+ 3 hrs), prevents significantly the rise in SGOT(Serum glutamic-oxaloacetic transaminase) activity, lipid peroxidation as well as liver necrosis. The protective effect is more evident at 1 mg and 5 mg eugenol doses than at 0.2 and 25 mg does. However, the decrease in microsomal G-6-pase activity by CCl4 treatment is not prevented by eugenol suggesting that the damage to endoplasmic reticulum is not protected[3].

细胞实验

Cells are seeded into 96-well plates and incubated overnight. The medium is replaced with fresh one containing the desired concentrations of eugenol. After 20 hrs, 10 μl of the WST-1 reagent is added to each well and the plates are incubated for 4 hrs at 37°C. The amount of formazan is quantified using ELISA reader at 450 nm of absorbance.(Only for Reference)

Cas No.

97-53-0

分子式

C10H12O2

分子量

164.204

别名

丁香酚;4-Allyl-2-methoxyphenol;Allylguaiacol;Eugenic acid;4-Allylguaiacol

储存和溶解度

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years