5,7-Dimethoxyflavone 是一种Kaempferia parviflora的主要成分,具有抗肿瘤、抗肥胖及抗炎活性。它对细胞色素P450 (CYP) 3As具有抑制作用,也是抗乳腺癌蛋白 (BCRP) 抑制剂。
产品描述
5,7-DIMETHOXYFLAVONE possessed remarkable leishmanicidal potential.
体外活性
The best in vitro trypanocidal activity for T. brucei rhodesiense was exerted by 7,8-dihydroxyflavone (50% inhibitory concentration [IC50], 68 ng/ml), followed by 3-hydroxyflavone, rhamnetin, and 7,8,3',4'-tetrahydroxyflavone (IC50s, 0.5 microg/ml) and catechol (IC50, 0.8 microg/ml).?The activity against T. cruzi was moderate, and only Chrysin dimethylether and 3-hydroxydaidzein had IC50s less than 5.0 microg/ml.
Cas No.
21392-57-4
分子式
C17H14O4
分子量
282.295
储存和溶解度
DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years