GSK8612 是一种具有高度选择性的TBK1强效抑制剂，其 pIC50=6.8。

GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8) .

In cellular assays, GSK8612 inhibited toll-like receptor (TLR)3-induced interferon regulatory factor (IRF)3 phosphorylation in Ramos cells and type I interferon (IFN) secretion in primary human mononuclear cells. In THP1 cells, GSK8612 was able to inhibit secretion of interferon-beta (IFNβ) in response to dsDNA and cGAMP, the natural ligand for STING.

2361659-62-1

C17H17BrF3N7O2S

520.33

DMSO:100 mg/mL (192.19 mM)
H2O:Insoluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years