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methionine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
methionine图片
CAS NO:348-67-4
包装:1 g
市场价:545元

产品名称
MRX-1024
D-Methionine
产品介绍
Methionine (MRX-1024; D-Methionine) 是一种有效的化学保护剂,它还可以通过激活 GABAA 受体来抑制神经元活性。

产品描述

Methionine (MRX-1024; D-Methionine) is an effective chemoprotective agent which can also inhibit the neuronal activity through GABAA receptor activation.

体外活性

The incubation of human plasma with Methionine (D-methionine) and CP leads to the formation of a Pt-D-methionine complex independent of the order of addition. In plasma, an early CP hydrolysis product reacts with Methionine to form a 1:1 complex that is followed by the formation of a 2:1 compound at a later time point. The formation of these Pt-D-methionine species plays an important role in the processes by which Methionine protects mammalian organisms against CP-induced toxicities[2].

体内活性

When Methionine (D-methionine) is administered along with cisplatin the cell density is 0.8±0.070 (SEM), significantly larger than in rats treated with only cisplatin (P<0.01) while not significantly different from controls or from animals treated only with D-methionine (P>0.05). When Methionine is administered alone the average cell density is 0.95±0.099 (SEM) and not significantly different from controls (P>0.05)[3].

Cas No.

348-67-4

分子式

C5H11NO2S

分子量

149.21

别名

MRX-1024;D-Methionine

储存和溶解度

H2O:22.5mg/mL (150.8mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years